General Information

  • ID:  hor005161
  • Uniprot ID:  P34964
  • Protein name:  Neuromedin-U-25
  • Gene name:  NMU
  • Organism:  Sus scrofa (Pig)
  • Family:  NmU family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006940 regulation of smooth muscle contraction; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  FKVDEEFQGPIVSQNRRYFLFRPRN
  • Length:  25(1-25)
  • Propeptide:  FKVDEEFQGPIVSQNRRYFLFRPRN
  • Signal peptide:  NA
  • Modification:  T25 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates uterine smooth muscle contraction and causes selective vasoconstriction.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NMUR2, NMUR1
  • Target Unid:  F1RQB8, A0A5G2QYE0
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P34964-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P34964-F1.pdbhor005161_AF2.pdbhor005161_ESM.pdb

Physical Information

Mass: 357179 Formula: C144H216N42O38
Absent amino acids: ACHMTW Common amino acids: FR
pI: 10.43 Basic residues: 5
Polar residues: 5 Hydrophobic residues: 8
Hydrophobicity: -96.8 Boman Index: -8469
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 54.4
Instability Index: 4104.8 Extinction Coefficient cystines: 1490
Absorbance 280nm: 62.08

Literature

  • PubMed ID:  3839674
  • Title:  Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord.